shared a link post in group #Biohackers Connect
A major new paper reframes aging as a systems failure of epigenetic information. Not wear and tear but a software problem. This is what the Information Theory of Aging predicts and, if correct, means aging is reversible.
#Biohackers Connect #Science is awesome 🧬🦾🚀🤯 #Healthspan Advocates
nature.com/articles/s4158..
www.nature.com
Systemic epigenetic dysregulation as a driver of ageing and a therapeutic target - Nature Reviews Molecular Cell Biology
This Review presents a systems-level framework of how epigenetic dysregulation drives ageing, including through deterioration of nuclear architecture, dysregulation of epigenetic memory, nucleosome alterations and transcription reprogramming. These processes interact and augment gene-expression failures, and thus represent promising potential therapeutic targets.