A study published in the Journal of the International Society of Sports Nutrition tested how melatonin interacts with resistance exercise in trained men and women. Researchers compared 0.5 mg, 5 mg, and placebo before a heavy leg press protocol while tracking growth hormone, somatostatin, and other markers across three hours of testing. Beyond the hormone spikes, one of the most valuable insights was the safety profile: melatonin raised GH without altering blood pressure, heart rate, or blood chemistry—and participants showed no drop in strength or performance. This suggests that melatonin’s effects are context-dependent, tied to circadian rhythms: in bright afternoon conditions it acted as a hormonal regulator, not a sedative. By lowering somatostatin, the natural “brake” on GH release, it created an environment more favorable for recovery and growth. The broader takeaway is that melatonin may play a dual role—supporting GH release during sleep and, under the right conditions, amplifying the anabolic signal of training. It’s an early look at how a supplement often thought of only for rest could also be leveraged to enhance adaptation in athletes. #Biohackers Connect