The Social Community for Biohackers Connect

entreresource.medium.com

Ozempic Cost Me 15 lbs of Muscle — This $69 Supplement Worked Better

I have written about the power of semaglutide several times now. Read the article below next if you want to see my overly analyzed results Don’t let anyone fool you, these drugs flat out work and…

www.newyorker.com

The End of Children

Birth rates are crashing around the world. Should we be worried?

www.youtube.com

Ketamine: Benefits and Risks for Depression, PTSD & Neuroplasticity | Huberman Lab Podcast

In this episode, I explain how ketamine causes rewiring of brain circuits and dissociative states to relieve symptoms of depression and post-traumatic stress disorder (PTSD). I explain how ketamine impacts both the brain’s glutamate and its endogenous opioid pathways, which together regulate mood and well-being. I discuss how ketamine therapy is used clinically to treat major depression, bipolar depression, obsessive-compulsive disorder (OCD), suicidality and other psychiatric challenges. I also describe how ketamine causes the subjective effects of dissociation and euphoria and, at higher doses, is an anesthetic. I compare the different routes of ketamine administration, dosages and forms of ketamine, and if micro-dosing ketamine is effective. I also highlight the potential risks of recreational ketamine use (and the colloquial term ‘K-holes’). This episode should interest anyone interested in ketamine, treatments for depression, neuroplasticity mechanisms, psychiatry and mental health. #HubermanLab #Science Thank you to our sponsors AG1: https://drinkag1.com/huberman ROKA: https://roka.com/huberman Eight Sleep: https://eightsleep.com/huberman LMNT: https://drinklmnt.com/huberman Supplements from Momentous https://www.livemomentous.com/huberman Social & Website Instagram: https://www.instagram.com/hubermanlab Threads: https://www.threads.net/@hubermanlab Twitter: https://twitter.com/hubermanlab Facebook: https://www.facebook.com/hubermanlab TikTok: https://www.tiktok.com/@hubermanlab LinkedIn: https://www.linkedin.com/in/andrew-huberman Website: https://hubermanlab.com Newsletter: https://hubermanlab.com/neural-network Articles Antidepressant effects of ketamine in depressed patients: https://bit.ly/44YTGxY Attenuation of antidepressant and antisuicidal effects of ketamine by opioid receptor antagonism: https://go.nature.com/3qesrR8 atai Life Sciences Announces Results from Phase 2a Trial of PCN-101 (R-ketamine) for Treatment-Resistant Depression: https://bit.ly/47j6wsC Comparative effects of (S)-ketamine and racemic (R/S)-ketamine on psychopathology, state of consciousness and neurocognitive performance in healthy volunteers: https://bit.ly/44WMxOR Ketamine Metabolite (2R,6R)-Hydroxynorketamine Interacts with μ and κ Opioid Receptors: https://bit.ly/44e4SWB Other Resources The Science & Treatment of Bipolar Disorder (Huberman Lab episode): https://hubermanlab.com/the-science-and-treatment-of-bipolar-disorder/ Timestamps 00:00:00 Ketamine 00:02:29 Sponsors: ROKA & Eight Sleep 00:05:13 Ketamine & PCP; Clinical & Recreational Use 00:09:00 Depression & Current Treatments 00:15:17 Preclinical Models of Depression & Ketamine; “Learned Helplessness” 00:22:11 Ketamine & Clinical Uses; Depression & Suicidality 00:28:32 Ketamine & Other Psychiatric Challenges; Relief & Durability 00:33:24 Sponsor: AG1 00:34:29 NMDA Receptor & Neuroplasticity 00:41:36 Excitatory & Inhibitory Communication, Seizure, NMDA Receptors & Ketamine 00:48:26 How Ketamine Functions in Brain; Acute & Long-Term Effects 00:55:36 Brain-Derived Neurotrophic Factor (BDNF) & Ketamine Therapy 01:02:28 Sponsor: LMNT 01:03:40 Ketamine & Opioid Pathway 01:10:00 Divergent Mechanisms of Immediate & Long-Term Effects 01:15:45 Habenula, Pro-Depressive Behaviors & Ketamine Therapy 01:20:36 Ketamine & Context-Dependent Strategy; Reward Pathway 01:22:45 Dissociative States 01:26:04 Doses & Routes of Administration; “K-holes”; Risk & Caution 01:32:25 Ketamine Forms; R-, S- vs R/S- Ketamine; Micro-Dosing 01:38:24 Ketamine: Effects & Therapy 01:40:40 Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous, Social Media, Neural Network Newsletter The Huberman Lab podcast is for general informational purposes only and does not constitute the practice of medicine, nursing or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast or materials linked from this podcast is at the user’s own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professionals for any such conditions. Title Card Photo Credit: Mike Blabac - https://www.blabacphoto.com

www.nytimes.com

Ozempic Could Crush the Junk Food Industry. But It Is Fighting Back.

As revolutionary new weight-loss drugs turn consumers off ultraprocessed foods, the industry is on the hunt for new products.

blogs.nvidia.com

Massive Foundation Model for Biomolecular Sciences Now Available via NVIDIA BioNeMo

Evo 2, a powerful biomolecular AI model, provides insights into DNA, RNA and proteins across diverse species.

www.nature.com

Paralysed man stands again after receiving ‘reprogrammed’ stem cells

Another man also regained some movement, but two others experienced minimal improvement.

lithub.com

How Big Pharma and Big Tech Collude To Exploit Basic Human Needs

What makes technological change happen? How are technologies—the artifacts, systems, and infrastructures that intervene in and reshape the material world—developed? Contrary to popular imagination,…

www.nature.com

Individual and additive effects of vitamin D, omega-3 and exercise on DNA methylation clocks of biological aging in older adults from the DO-HEALTH trial - Nature Aging

Applying epigenetic clocks to samples from the DO-HEALTH trial, Bischoff-Ferrari et al. report a small protective effect of omega-3 supplementation over 3 years on several clocks and an additive prote

www.wired.com

The Psychedelic Scientist Who Sends Brains Back to Childhood

Kids soak up new skills, adults not so much. But neuroscientist Gül Dölen might have found a way—with drugs—to help grown-ups learn like littles.

sfstandard.com

Goodnight, sleep tight, don’t forget your caffeine pill

Tech founders are using caffeine to hack sleep — and it’s not as dumb as it sounds.