Are psychadelics accepted, embraced or excluded by Biohackers overall?  Would you consider it?

Magic Mushrooms. LSD. Ketamine. The Drugs That Power Silicon Valley.

Are psychadelics accepted, embraced or excluded by Biohackers overall?  Would you consider it? Magic Mushrooms. LSD. Ketamine. The Drugs That Power Silicon Valley. Entrepreneurs including Elon Musk and Sergey Brin are part of a psychedelic movement that proponents hope will expand minds, enhance lives and produce business breakthroughs. https://www.wsj.com/articles/silicon-valley-microdosing-ketamine-lsd-magic-mushrooms-d381e214?mod=djemalertNEWS&utm_source=sg&utm_medium=email&utm_campaign=article_email&utm_content=article-10761

Sam Mendoza

Psychedelics are making a comeback. Are we ready for them this time?

https://pierz-newton-john.medium.com/psychedelics-changed-my-life-can-they-change-the-world-7b07f2a0cbd1

#Biohackers Connect

Biohackers Connect

Psychedelics are making a comeback. Are we ready for them this time?  https://pierz-newton-john.medium.com/psychedelics-changed-my-life-can-they-change-the-world-7b07f2a0cbd1  #Biohackers Connect

Psychedelics are making a comeback. Are we ready for them this time?

Psychedelics Changed My Life. Can They Change the World?

Nate

Psychedelics are helpful to open our minds and expose us to new perspectives, but the healing work must continue after the experience

There's a balance and no silver bullets!  Many people seek out psychedelics for healing but fail to implement the necessary daily routines and mental health practices to maintain the benefits, leading to a "revolving door" of temporary relief.

Integrating the insights from psychedelic experiences requires consistent meditation, journaling, somatic work, and other practices to process emotions and change behavior, not just relying on the temporary "high."

 #MEDITATION (mindfulness) 

https://medium.com/black-bear-recovery/the-revolving-door-of-psychedelics-057542a8133d

MEDITATION (mindfulness)

Psychedelics are helpful to open our minds and expose us to new perspectives, but the healing work must continue after the experience  There's a balance and no silver bullets!  Many people seek out psychedelics for healing but fail to implement the necessary daily routines and mental health practices to maintain the benefits, leading to a "revolving door" of temporary relief.  Integrating the insights from psychedelic experiences requires consistent meditation, journaling, somatic work, and other practices to process emotions and change behavior, not just relying on the temporary "high."   #MEDITATION (mindfulness)   https://medium.com/black-bear-recovery/the-revolving-door-of-psychedelics-057542a8133d

The Revolving Door of Psychedelics

Todd Smith

Psychedelic drugs, such as LSD, psilocybin, and DMT, to treat brain injuries and disorders. Recent research suggests that these drugs can reopen critical learning periods in the brain, allowing patients to relearn lost skills and acquire new ones. The drugs may also reduce inflammation, stimulate neuron growth, and activate receptors that can help protect the brain from injury. The article highlights several studies that have shown promising results, including improved social skills in adults with autism and reduced cognitive deficits in veterans with traumatic brain injuries. The article also notes that novel psychedelics engineered to remove the altered consciousness may be particularly effective for brain injuries.

https://www.nationalgeographic.com/premium/article/psychedelics-lsd-heal-brain-injury
 
#Brain Journey Network 
#Pop NEUROSCIENCE 
#Biohackers Connect

Brain Journey Network

Pop NEUROSCIENCE

Psychedelic drugs, such as LSD, psilocybin, and DMT, to treat brain injuries and disorders. Recent research suggests that these drugs can reopen critical learning periods in the brain, allowing patients to relearn lost skills and acquire new ones. The drugs may also reduce inflammation, stimulate neuron growth, and activate receptors that can help protect the brain from injury. The article highlights several studies that have shown promising results, including improved social skills in adults with autism and reduced cognitive deficits in veterans with traumatic brain injuries. The article also notes that novel psychedelics engineered to remove the altered consciousness may be particularly effective for brain injuries.  https://www.nationalgeographic.com/premium/article/psychedelics-lsd-heal-brain-injury   #Brain Journey Network  #Pop NEUROSCIENCE  #Biohackers Connect

Psychedelic drugs such as DMT and Ecstasy may offer a unique treatment pathway for various brain injuries and diseases because of their potency, helping patients learn lost and new skills.

How psychedelic drugs help heal the brain from traumatic injury

"I am high the whole bloody day!  I don't need drugs.  I don't need drinks.  I have drunk, I took drugs, I smoked, I did it all, but nmow I do it all without anything!"

 #Breathwork #MEDITATION (mindfulness) https://andycmurphy1.medium.com/wim-hofs-simple-confession-says-it-all-51d5b3318d5e

Breathwork

"I am high the whole bloody day!  I don't need drugs.  I don't need drinks.  I have drunk, I took drugs, I smoked, I did it all, but nmow I do it all without anything!"   #Breathwork #MEDITATION (mindfulness) https://andycmurphy1.medium.com/wim-hofs-simple-confession-says-it-all-51d5b3318d5e

I think this is my favourite thing he’s ever said

Wim Hof’s Simple Confession Says It All

Huberman's excellent podcast episode in which he discusses Ketamine at length. Says he, “In this episode, I explain how ketamine causes rewiring of brain circuits and dissociative states to relieve symptoms of depression and post-traumatic stress disorder (PTSD). I explain how ketamine impacts both the brain’s glutamate and its endogenous opioid pathways, which together regulate mood and well-being. I discuss how ketamine therapy is used clinically to treat major depression, bipolar depression, obsessive-compulsive disorder (OCD), suicidality and other psychiatric challenges. I also describe how ketamine causes the subjective effects of dissociation and euphoria and, at higher doses, is an anesthetic. I compare the different routes of ketamine administration, dosages and forms of ketamine, and if micro-dosing ketamine is effective. I also highlight the potential risks of recreational ketamine use (and the colloquial term ‘K-holes’). This episode should interest anyone interested in ketamine, treatments for depression, neuroplasticity mechanisms, psychiatry and mental health.”

https://www.youtube.com/watch?v=Rxmv7rT9leo
 #Biohackers Connect

We often yearn for that elusive silver bullet, the mystical remedy that will whisk away our troubles without requiring any effort. But deep down, there’s a nagging fear—a whisper that reminds us of the price we might pay for such shortcuts.
Ketamine therapy, with its potential to alleviate mental health struggles, can seem like one of those magical pills. Yet, as shared here, it’s a nuanced journey—one that intertwines science, personal reflections, and vulnerability.

https://medium.com/@profgalloway/prof-k-a21499a99514

We often yearn for that elusive silver bullet, the mystical remedy that will whisk away our troubles without requiring any effort. But deep down, there’s a nagging fear—a whisper that reminds us of the price we might pay for such shortcuts. Ketamine therapy, with its potential to alleviate mental health struggles, can seem like one of those magical pills. Yet, as shared here, it’s a nuanced journey—one that intertwines science, personal reflections, and vulnerability.  https://medium.com/@profgalloway/prof-k-a21499a99514

I experienced ketamine therapy a few weeks ago and, after discussing it on Pivot and Prof G pods, I’ve received a great deal of inquiries…

Prof K

Cyril

Huberman's excellent podcast episode in which he discusses Ketamine at length. Says he, “In this episode, I explain how ketamine causes rewiring of brain circuits and dissociative states to relieve symptoms of depression and post-traumatic stress disorder (PTSD). I explain how ketamine impacts both the brain’s glutamate and its endogenous opioid pathways, which together regulate mood and well-being. I discuss how ketamine therapy is used clinically to treat major depression, bipolar depression, obsessive-compulsive disorder (OCD), suicidality and other psychiatric challenges. I also describe how ketamine causes the subjective effects of dissociation and euphoria and, at higher doses, is an anesthetic. I compare the different routes of ketamine administration, dosages and forms of ketamine, and if micro-dosing ketamine is effective. I also highlight the potential risks of recreational ketamine use (and the colloquial term ‘K-holes’). This episode should interest anyone interested in ketamine, treatments for depression, neuroplasticity mechanisms, psychiatry and mental health.”  https://www.youtube.com/watch?v=Rxmv7rT9leo  #Biohackers Connect

In this episode, I explain how ketamine causes rewiring of brain circuits and dissociative states to relieve symptoms of depression and post-traumatic stress disorder (PTSD). I explain how ketamine impacts both the brain’s glutamate and its endogenous opioid pathways, which together regulate mood and well-being. I discuss how ketamine therapy is used clinically to treat major depression, bipolar depression, obsessive-compulsive disorder (OCD), suicidality and other psychiatric challenges. I also describe how ketamine causes the subjective effects of dissociation and euphoria and, at higher doses, is an anesthetic. I compare the different routes of ketamine administration, dosages and forms of ketamine, and if micro-dosing ketamine is effective. I also highlight the potential risks of recreational ketamine use (and the colloquial term ‘K-holes’). This episode should interest anyone interested in ketamine, treatments for depression, neuroplasticity mechanisms, psychiatry and mental health.

#HubermanLab #Science 

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Articles 
Antidepressant effects of ketamine in depressed patients: https://bit.ly/44YTGxY
Attenuation of antidepressant and antisuicidal effects of ketamine by opioid receptor antagonism: https://go.nature.com/3qesrR8
atai Life Sciences Announces Results from Phase 2a Trial of PCN-101 (R-ketamine) for Treatment-Resistant Depression: https://bit.ly/47j6wsC 
Comparative effects of (S)-ketamine and racemic (R/S)-ketamine on psychopathology, state of consciousness and neurocognitive performance in healthy volunteers: https://bit.ly/44WMxOR
Ketamine Metabolite (2R,6R)-Hydroxynorketamine Interacts with μ and κ Opioid Receptors: https://bit.ly/44e4SWB

Other Resources
The Science & Treatment of Bipolar Disorder (Huberman Lab episode): https://hubermanlab.com/the-science-and-treatment-of-bipolar-disorder/

Timestamps
00:00:00 Ketamine
00:02:29 Sponsors: ROKA & Eight Sleep
00:05:13 Ketamine & PCP; Clinical & Recreational Use
00:09:00 Depression & Current Treatments
00:15:17 Preclinical Models of Depression & Ketamine; “Learned Helplessness” 
00:22:11 Ketamine & Clinical Uses; Depression & Suicidality 
00:28:32 Ketamine & Other Psychiatric Challenges; Relief & Durability 
00:33:24 Sponsor: AG1
00:34:29 NMDA Receptor & Neuroplasticity
00:41:36 Excitatory & Inhibitory Communication, Seizure, NMDA Receptors & Ketamine
00:48:26 How Ketamine Functions in Brain; Acute & Long-Term Effects
00:55:36 Brain-Derived Neurotrophic Factor (BDNF) & Ketamine Therapy
01:02:28 Sponsor: LMNT
01:03:40 Ketamine & Opioid Pathway 
01:10:00 Divergent Mechanisms of Immediate & Long-Term Effects
01:15:45 Habenula, Pro-Depressive Behaviors & Ketamine Therapy
01:20:36 Ketamine & Context-Dependent Strategy; Reward Pathway
01:22:45 Dissociative States
01:26:04 Doses & Routes of Administration; “K-holes”; Risk & Caution
01:32:25 Ketamine Forms; R-, S- vs R/S- Ketamine; Micro-Dosing 
01:38:24 Ketamine: Effects & Therapy
01:40:40 Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous, Social Media, Neural Network Newsletter

The Huberman Lab podcast is for general informational purposes only and does not constitute the practice of medicine, nursing or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast or materials linked from this podcast is at the user’s own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professionals for any such conditions.

Title Card Photo Credit: Mike Blabac - https://www.blabacphoto.com