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NAD+ in Aging: Role of Nicotinamide Riboside and Nicotinamide Mononucleotide

In this episode, Rhonda explains what NAD+ is and why it declines with age. She discusses some of the popular NAD+ boosters like nicotinamide riboside and nicotinamide mononucleotide, what animal and human data says and some concluding thoughts. NAD+ is crucial for our survival. Small amounts of it can be obtained in the diet, but the body recycles it to get most of what it needs. Unfortunately, day to day living plus normal aging can cause NAD+ levels to drop. This causes metabolic and mitochondrial dysfunction, as well as many of the other problems and conditions associated with aging like elevated DNA damage. NAD+ levels can go up when we exercise or fast, but NAD+ precursors like nicotinamide riboside and nicotinamide mononucleotide can also increase NAD+ levels in a dose-dependent manner. However, most of the data on NAD+ boosters comes from animal studies. Whether these boosters are effective – and safe – long-term in humans is still a big question. ▶︎ Get the episode's show notes, timeline, and more https://www.foundmyfitness.com/episodes/nad-nr-nmn Chapters 00:00:00 - Introduction 00:01:01 - Aging 00:02:47 - Overview 00:07:35 - Depletion 00:09:19 - Supplementation 00:11:26 - Animal studies 00:13:47 - Cancer 00:15:57 - Dosage 00:25:44 - Human data 00:28:25 - Storage 00:29:00 - Recap ▶︎ Detailed overview of NAD+ https://www.foundmyfitness.com/topics/nad ▶︎ Detailed overview of nicotinamide riboside https://www.foundmyfitness.com/topics/nicotinamide-riboside ▶︎ Detailed overview of nicotinamide mononucleotide https://www.foundmyfitness.com/topics/nicotinamide-mononucleotide ▶︎ Did you enjoy this podcast? If you want to support me in getting more of this free information out to the public, please consider becoming an FMF premium member! In doing so, you'll also get access to exclusive member benefits, such as a private podcast feed offering early access and occasional bonus episodes, monthly live Q&As with me, a members-only library that includes presentation slides with all of the supporting figures, graphics, references, and quotes. Also included are Rhonda's private notes on topics discussed in the podcast, bi-monthly member-exclusive Science News Digest email, and more. Thank you for your consideration! Learn more here: https://www.foundmyfitness.com/premium ▶︎ Gain valuable insights by running your raw genetic data through the FoundMyFitness report https://www.foundmyfitness.com/genetics/sirtuin