sounds fantastical but I occasionally hear people say that pharma companies would not be interested in curing Long Covid, ME/CFS, etc., because they’d prefer to sell you drugs for life. But curative gene therapies can be sold for millions of dollars per patient, or is that just at the start?


https://medium.com/neodotlife/gene-therapies-for-eternal-youth-43589506ac42

Gene Therapies for Eternal Youth

sounds fantastical but I occasionally hear people say that pharma companies would not be interested in curing Long Covid, ME/CFS, etc., because they’d prefer to sell you drugs for life. But curative gene therapies can be sold for millions of dollars per patient, or is that just at the start?   https://medium.com/neodotlife/gene-therapies-for-eternal-youth-43589506ac42

Todd Smith

The FDA approved the world’s first therapy using gene-editing Crispr technology. Exa-cel — a treatment for sickle-cell disease developed by Vertex Pharmaceuticals and Crispr Therapeutics — works by genetically manipulating patients’ cells. Unlike medicines that treat diseases, Crispr targets their root causes, creating a potential one-and-done cure for diseases like cancer and diabetes. It’s poised to transform medicine, though its exorbitant cost (Exa-cel rings up at $2.2M/patient) is a roadblock.

https://www.scientificamerican.com/article/fda-approves-first-crispr-gene-editing-treatment-for-sickle-cell-disease/#:~:text=On%20December%208%20the%20U.S.,blood%20cell%20shape%20and%20function.

The FDA approved the world’s first therapy using gene-editing Crispr technology. Exa-cel — a treatment for sickle-cell disease developed by Vertex Pharmaceuticals and Crispr Therapeutics — works by genetically manipulating patients’ cells. Unlike medicines that treat diseases, Crispr targets their root causes, creating a potential one-and-done cure for diseases like cancer and diabetes. It’s poised to transform medicine, though its exorbitant cost (Exa-cel rings up at $2.2M/patient) is a roadblock.  https://www.scientificamerican.com/article/fda-approves-first-crispr-gene-editing-treatment-for-sickle-cell-disease/#:~:text=On%20December%208%20the%20U.S.,blood%20cell%20shape%20and%20function.

Sickle cell disease causes red blood cells to take on a sickle-like shape, making them fragile and less able to transport oxygen.

Most people with sickle cell disease who received a new gene editing 

FDA Approves First CRISPR Gene Editing Treatment for Sickle Cell Disease

Sam Mendoza

5 years away for the last 50 years.  I’ll believe when I’m a mutant!

🤯 this is way better than the article i shared in the OP.  

sleep (4 hours for full rest)
rejuvenation gene therapy
Skin to reflect UV light
engineer gut health to metabolize food that's easier to grow on Mars
night vision

I can't wait to be a "mutant" superhero 🦸‍♂️ !

Nate

🤯 this is way better than the article i shared in the OP.    sleep (4 hours for full rest) rejuvenation gene therapy Skin to reflect UV light engineer gut health to metabolize food that's easier to grow on Mars night vision  I can't wait to be a "mutant" superhero 🦸‍♂️ !

Jerome Cody

This talk was recorded live at the All-In Summit 2023 at Royce Hall on UCLA's campus in Los Angeles. 

(0:00) Besties welcome Dr. Nicole Paulk to All-In Summit ‘23! 
(0:59) An introduction to Gene Therapy
(2:18) Three eras of modern medicine
(4:49) Living medicines
(6:35) Congenital blindness and other rare diseases
(9:37) Gene therapy applications for broad use, including cancer
(12:00) Immunosurveillance and immunotherapy
(14:44) Brain cancer test
(16:34) DEC2 mutation to reduce the need for sleep
(17:45) Gene therapy for people living on Mars
(18:40) Bestie Q&A: FDA hurdles and aging as a disease state
(21:16) Biotech’s valley of death
(23:52) Night vision and other human enhancements
(26:32) Fundraising 

Follow Nicole:
https://twitter.com/Nicole_Paulk

Follow the besties: 
https://twitter.com/chamath
https://linktr.ee/calacanis
https://twitter.com/DavidSacks
https://twitter.com/friedberg

Follow the pod:
https://twitter.com/theallinpod
https://linktr.ee/allinpodcast

Intro Music Credit:
https://rb.gy/tppkzl
https://twitter.com/yung_spielburg

Intro Video Credit:
https://twitter.com/TheZachEffect

Relevant links:
https://twitter.com/SirenBio
https://sirenbiotechnology.com/